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Due to its long half-life, women of childbearing potential should stop treatment at least 2 months before a planned pregnancy and discuss alternative glucose-lowering therapies with their healthcare provider

Watch for: Whether dysesthesia incidence differs between diabetes and general obesity populations Time-to-onset patterns across trials Resolution rates in patients who reduced or stopped treatment Impact on discontinuation in non-osteoarthritis populations Subgroup analyses identifying who develops dysesthesia most Conclusion Dysesthesia affecting 12.520.9% of patients at retatrutide's highest dose depending on population is not a minor detail