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Stuenkel CA, Davis SR, Gompel A, et al

Carbaglu ), a structural analog of N -acetylglutamate, is an effective and generally well-tolerated option for the treatment of hyperammonaemia due to propionic, methylmalonic and isovaleric acidurias

Known risk factors include, among others: the expected benefits and opportunities related to the collaboration and the companion diagnostics may not be realized or may take longer to realize than expected due to challenges and uncertainties inherent in product research and development

Notably, the proportion of treatment nave Mounjaro patients declined around the time that Mounjaro experienced a supply shortage and scaled back marketing, including transitional assistance, to ensure that product access and supply could be maintained for patients with diabetes as intended