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NNMT inhibition doesn't directly affect gut motility, so prolonged GI symptoms suggest an individual sensitivity rather than a universal mechanism

In animal models, ranolazine administration following doxorubicin treatment improved left ventricular function, attenuated cardiac injury, and restored cognitive function [146]

Temporarily discontinuing self-initiated supplements whilst awaiting medical review is reasonable if symptoms are troublesome, particularly if you began supplementation without confirmed deficiency

LA deficiency leads to an impaired more permeable skin barrier and the topical application of LA-rich sunflower oil can fix this issue rapidly (while oleic-rich olive oil did not have the same barrier repairing effect)