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One challenge to elucidating a mechanistic role for GLP-1Rs stems from their complex expression across multiple brain regions (1012), including the lateral septal nucleus (LSc), substantia nigra, ventral tegmental area (VTA), amygdala, nucleus accumbens (ACB), hippocampus, several regions of the hypothalamus (paraventricular nucleus of the hypothalamus [PVH], arcuate nucleus [ARH]), and hindbrain

Kamen DL, Aranow C

Bone changes post-sleeve gastrectomy in relation to body mass and hormonal changes

When you eat more food than you need, excess nutrients are either excreted or broken down and converted into fat so it can be stored for later