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What it is not is a DHT blocker
NNMT expression is elevated in adipose tissue in obesity models
By removing these senescent cells, FOXO4-DRI may give the body a better environment for stem cells to become active and help renew tissues
Total weight loss at 48-68 weeks on the combination is difficult to predict without clinical trial data, but based on individual compound data (retatrutide at 24-28.7% and the additive benefit seen with CagriSema), a reasonable estimate for the combination is 25-35% total body weight reduction in high responders
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