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A 2025 meta-analysis of 16 studies involving 6,098 participants found no statistically significant difference between intramuscular, oral, and sublingual B12 supplementation routes (p=0.270)
In addition, B12 injections can help reduce the risk of: Heart disease Neurological disorders Stroke Vision loss Problems with memory and thinking Infertility Effect of vitamin B12 starts to work within two to three days with maximum benefits
B12 must be transported and absorbed intracellularly - only there does it benefit health and kick off important downstream processes
For B12 to be absorbed properly, it must bind with a protein called "intrinsic factor," which is produced in the stomach
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