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Unconventional protein secretionnew insights into the pathogenesis and therapeutic targets of human diseases

General symptoms of thiamine deficiency include confusion, psychomotor retardation, impaired memory and cognitive function, and ataxia (36, 40)

Wagstaff, R.N

Interestingly, despite the lack of consistent actions of metformin in terms of metabolic profiles, treatment with the insulin sensitizer caused a complete normalization of ovarian cyclicity, pointing to a discernible reproductive effect of metformin in some PCOS conditions, in line with clinical literature 68 , although conflictive results have been reported also 69