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While agonist peptides based on either scaffold are potent in rat obesity models 2,10,11,12,13 , only a transient weight loss effect is observed with sCT in mouse diet-induced obesity (DIO) models 14 , indicating that there may be distinctions in the mode of action of individual dual agonists

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Notably, no lethal dose could be determined in animals (no LD50 established)

Influence of glucagon on GFR and on urea and electrolyte excretion: direct and indirect effects