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These findings indicate that hyperglycemia induces Mller cell ferroptosis via iron overload, lipid peroxidation and Xc - GSHGPX4 axis dysfunction, which further exacerbates neuroinflammation through microglial reactivation and impairs the BRB
These effects highlight ipamorelins potential as a therapeutic agent for neurodegenerative diseases by protecting neurons and reducing inflammation (9)
IL-6 shows a synergistic effect with other mediators of metabolic disease, collectively contributing to the progression of other obesity-associated comorbidities such as CAD and T2DM [64, 69]
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