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Mitochondrial permeability transition pores (mPTP), a nonspecific channel located in the mitochondrial membrane, attribute to the increased permeability of the mitochondrial inner membrane after opening

However, in the inflammatory state, glucocorticoid concentrations suppress the immune response mainly by inhibiting the transmission of PRR, Fc receptors, and cytokine signaling, thereby shortening the duration of the immune response (92, 93)

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Despite this, there are instances where the ability to synthesize GSH, and in turn establish an adaptive response is compromised