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Estrogens in Neurodegeneration Estrogens and Their Role in Cell (Neuronal) Survival: Neuroprotection Several in vitro and in vivo studies indicate that estradiol, and metabolites derived from phytoestrogens such as trans-resveratrol, are capable of promoting survival in neurons subjected to diverse stress conditions (Robb and Stuart, 2010

Also, recent comprehensive reviews summarizing multiple in vivo studies confirm SINs capability to inhibit microglial activation, reduce oxidative stress, and enhance neuronal survival after cerebral ischemia (136)

It is often explored in laboratory settings focused on cellular activity and regeneration-related research

(5) Yanqing Li, Chi Zhang, Haicheng Cheng, LinYan Lv, Xinning Zhu, Menghui Ma, Zhenhan Xu, Junxian He, Yun Xie, Xing Yang, Xiaoyan Liang, Chunhua Deng, Guihua Liu, FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells, Experimental Gerontology, Volume 195, 2024, 112522