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Drug Des Devel Ther 13:27452757 Martins FL, Bailey MA, Girardi ACC (2020) Endogenous activation of glucagon-like peptide-1 receptor contributes to blood pressure control: role of proximal tubule Na+/H+ exchanger isoform 3, renal angiotensin II, and insulin sensitivity
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Weeks 1 through 4 at 2.5 mg represent the introduction phase
As an example, in experimental conditions with animal models (GLP-1R-null), TZP reduced appetite and food intake, liver glycogenolysis and gluconeogenesis, improved insulin sensibility (assessed by euglycemic clamp) and glucose disposal in white and brown adipose tissue, skeletal muscle, with body weight-dependent and independent effects (73)
