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Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
e.g., LEADER, SUSTAIN-6, EXSCEL, HARMONY Outcomes, REWIND, ELIXA, AMPLITUDE-O, SELECT) and other large-scale clinical programs (e.g., PIONEER, AWARD, LEAD, SCALE, STEP)
Cranial CT may show frontotemporal lobe atrophy, bilateral basal ganglia hypodensity changes, and other abnormalities [30]
Body Composition and Fat Metabolism (Weeks 4 to 8) GH activates lipolysis, particularly in visceral and subcutaneous fat
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