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Early administration of lactate in rat organotypic hippocampal slices after oxygen-glucose deprivation protected against neuronal death, decreased lesion size and showed better neurologic outcomes in a mouse model of middle cerebral artery occlusion (Berthet et al., 2011), in mouse cortical neuron cultures (Jourdain et al., 2016) and in rat cortex in vivo (Ros et al., 2001)
Kaempferol, for example, exerts anti-inflammatory effects by modulating the LPSTLR4NF-B and IRE1JNKCHOP pathways 513,514 but is poorly soluble and stable
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